Soft Tissue Tumors

Soft tissue tumors click to access explanations in the original CAP template

This is additional protocol for biopsy specimen of soft tissue tumors.

Microscopic descriptions:

- Tumor histology and immunohistochemical studies:

Adipocytic Tumors	Atypical spindle cell / pleomorphic lipomatous tumor Atypical lipomatous tumor Well-differentiated liposarcoma Dedifferentiated liposarcoma Myxoid liposarcoma (+% hypercellular area) Pleomorphic liposarcoma, NOS Epithelioid pleomorphic liposarcoma Myxoid pleomorphic liposarcoma
Fibroblastic / myofibroblastic / fibrohistiocytic tumors	Solitary fibrous tumor Desmoid-type fibromatosis Lipofibromatosis Adult fibrosarcoma Plexiform fibrohistiocytic tumor Giant cell fibroblastoma Dermatofibrosarcoma protuberans Fibrosarcomatous dermatofibrosarcoma protuberansa Myxofibrosarcoma Low-grade fibromyxoid sarcoma Sclerosing epithelioid fibrosarcoma Myofibroblastic sarcoma Superficial CD34-positive fibroblastic tumor Myxoinflammatory fibroblastic sarcoma
Histiocytic / giant cell rich tumors	Giant cell tumor of soft tissue Langerhans cell sarcoma True histiocytic sarcoma Malignant tenosynovial giant cell tumor Dendritic reticulum cell sarcoma Interdigitating reticulum cell sarcoma Fibroblastic reticulum cell sarcoma
Tyrosine kinase fusion tumors, RAS-MAP pathway	NTRK 1/2/3 fusion tumor BRAF fusion tumor RET fusion tumor RAF fusion tumor ALK fusion tumor, NOS Inflammatory myofibroblastic tumor Epithelioid inflammatory myofibroblastic sarcoma Infantile fibrosarcoma
Pericytic / myopericytic tumors	Glomus tumor, atypical / uncertain biologic potential Glomus tumor, malignant
Vascular tumors	Kaposiform hemangioendothelioma Papillary intralymphatic angioendothelioma Retiform hemangioendothelioma Composite hemangioendothelioma Pseudomyogenic hemangioendothelioma Kaposi sarcoma Epithelioid hemangioendothelioma with WWTR1::CAMTA1 fusion Epithelioid hemangioendothelioma with YAP1::TFE3 fusion Epithelioid hemangioendothelioma, NOS Epithelioid angiosarcoma Radiation-associated angiosarcoma Lymphedema-associated angiosarcoma Angiosarcoma, NOS
Smooth Muscle Tumors	EBV-associated smooth muscle tumor Leiomyosarcoma
Skeletal Muscle Tumors	Embryonal rhabdomyosarcoma Alveolar rhabdomyosarcoma Pleomorphic rhabdomyosarcoma Spindle cell / sclerosing rhabdomyosarcoma NOS Congenital spindle cell rhabdomyosarcoma with VGLL2/NCOA2/CITED2 rearrangements Spindle cell / sclerosing rhabdomyosarcoma with MYOD1 mutation MYOD1-mutant spindle cell / sclerosing rhabdomyosarcoma Spindle cell rhabdomyosarcoma with FUS/EWSR1::TFCP2 or MEIS1::NCOA2 rearrangements Ectomesenchymoma
Peripheral nerve sheath tumors	Malignant peripheral nerve sheath tumor, NOS Epithelioid malignant peripheral nerve sheath tumor Malignant triton tumor Melanotic malignant peripheral nerve sheath tumor Malignant granular cell tumor Malignant perineurioma
Chondro-osseous Tumors	Extraskeletal osteosarcoma Mesenchymal chondrosarcoma Chondrosarcoma arising in synovial chondromatosis
Tumors of uncertain differentiation / additional round and spindle cell tumors	Hemosiderotic fibrolipomatous tumor Pleomorphic hyalinizing angiectatic tumor Atypical fibroxanthoma Pleomorphic dermal sarcoma Angiomatoid fibrous histiocytoma Myoepithelioma Mixed tumor, malignant Myoepithelial carcinoma Ossifying fibromyxoid tumor Phosphaturic mesenchymal tumor, malignant Synovial sarcoma Epithelioid sarcoma, distal classic type Epithelioid sarcoma, proximal large cell type Alveolar soft part sarcoma Clear cell sarcoma of soft tissue Extraskeletal myxoid chondrosarcoma Desmoplastic small round cell tumor (DSRCT) Round cell sarcoma with EWSR1::non ETS fusions CIC-rearranged sarcoma Sarcoma with BCOR genetic alterations PEComa, NOS PEComa, TSC2 mutated PEComa, TFE3 rearranged Intimal sarcoma
Extrarenal rhabdoid tumor
Undifferentiated sarcomas	Undifferentiated pleomorphic sarcoma Undifferentiated sarcoma NOS

- Histologic grade (FNCLCC grading): (mitoic counts adjusted to 22 mm eyepiece, 40x objective)
	- Histologic type:
	- Mitotic rate :
	- Tumor necrosis:
- Treatment effect:
- Lymphatic and / or Vascular Invasion:
+ Perineural invasion:

Surgical margins:

- Surgical margin:

Regional lymph nodes:

- Number of regional lymph nodes examined:
- Number of lymph nodes involved:
- Extracapsular spread:
- Size of largest metastatic deposit (mm), specify site:
- Size of largest lymph node involved (mm), specify site:

Distant Metastasis: Not applicable Not identified Non-regional lymph node(s) (specify): Lung (specify): Other (specify): Cannot be determined:

Pathologic stage classification (AJCC 8e):

- TNM Descriptors:	m (multiple primary tumors) r (recurrent) y (post treatment)
- Primary tumor (pT) (Head and neck):
- Primary tumor (pT) (Trunk and extremities):
- Primary tumor (pT) (Abdo and thorax visceral organs):
- Primary tumor (pT) (Retroperitoneum):
- Primary tumor (pT) (Orbit):
- Regional lymph nodes (pN):
- Distant metastasis (pM):

Additional pathologic findings:

+ Preresection treatment:	No known preresection therapy Chemotherapy performed Radiation therapy performed Therapy performed, type not specified Not specified
+ Other (specify):

- Additional notes: